The Tobacco Research in Youth (TRY) group is a team of researchers, led by Dr. Suchitra Krishnan-Sarin, in Yale's School of Medicine dedicated to developing and disseminating the optimal intervention for adolescent tobacco users. We aim to discover the best behavioral and pharmacological combination to enhance quit rates among high-school aged students. We have been recruiting and conducting prevention and cessation programs in over 14 local high schools in Connecticut since 2003. We are also conducting a lab based study for e-cigarette users to understand the reinforcement potential of these products, and how it is altered by the use of flavors which appear to enhance the appeal of these products in young smokers. Finally, we conduct school-wide tobacco surveys in Connecticut schools to assess perceptions, rates of use, and risk factors for initiation.